PROTEIN FOLDING ORDER PREDICTION METHOD

摘要

PPROBLEM TO BE SOLVED: To provide a method for identifying an order of folding a portion of a protein to be predicted, in three-dimensional protein structure prediction, by characteristics of an amino acid residue sequence of the protein. PSOLUTION: The method divides an amino acid residue sequence of a protein to be predicted into fragments of a length n (n=5-9), computes a standard deviation of an energy value based on multidimensional mean force field potential in different three-dimensional structures of the sequence fragment of each fragment, and predicts that three-dimensional structure folding proceeds in descending order of the standard deviation value. PCOPYRIGHT: (C)2008,JPO&INPIT