MIGRATION PROMOTER TO INJURED SITE OF NEURONAL PRECURSOR CELL

摘要

PPROBLEM TO BE SOLVED: To provide a new migration promoter to an injured site of a neuronal precursor cell, and an expression promoter of a migration-promoting factor gene of astrocyte. PSOLUTION: The migration promoter and the expression promoter of the migration-promoting factor gene contain a compound selected from baicalin, a pharmaceutically acceptable salt thereof, and hydrates thereof as a main component. The baicalin or the like increases the migration to the astrocyte of the neuronal precursor cell so as to be 1.5 times (p=0.012) more than that of a control group, and the migration of NPC so as to be 2.5 times more than the control group. Further, the baicalin or the like increases the mRNA of VEGF so as to be 2.7 times and the mRNA of MCP-1 so as to be 8.2 times more than those of the control group. PCOPYRIGHT: (C)2008,JPO&INPIT