Its use of human and obesity susceptibility gene encoding a member of the New lexical down family

摘要

Discloses the identification of a human obesity susceptibility gene In particular, the present invention, it may, for the treatment diagnosis of related disorders and obesity, and prevention, and used for drug screening as well as therapeutically effective . More specifically, it is related to susceptibility to obesity, the present invention discloses certain alleles of the contactin associated protein-like 2 (CNTNAP2) gene is a novel target for therapeutic intervention. Specific mutations of the expression product and in CNTNAP2 gene, and the present invention relates to a kit and diagnostic tools based on these mutations. Including, but not limited to, dyslipidemia low α hyperlipoproteinemia, familial combined hyperlipidemia, multiple metabolic abnormalities or insulin resistance syndrome X, coronary disease, diabetes and related complications, as well as, the present invention , it is possible to metabolic disorders and coronary heart disease, the diagnosis of predisposition, detection, prevention, and used in the treatment or /.