METHODS FOR COATING STENTS WITH DNA AND EXPRESSION OF RECOMBINANT GENES FROM DNA COATED STENTS IN VIVO

摘要

PPROBLEM TO BE SOLVED: To provide an intravascular DNA coated stent, methods for expressing recombinant genes in vivo using the DNA coated stents, and methods for treating coronary and peripheral vascular diseases, particularly restenosis and vein by-pass grafts, using the DNA coated stents. PSOLUTION: A device by this invention includes an intravascular stent coated with a polymerizable matrix and DNA to code a therapeutically useful protein. In one embodiment, the stent is a polymer stent or a metallic steel stent. In another embodiment, the stent is made of stainless steel. PCOPYRIGHT: (C)2008,JPO&INPIT