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The method of appraising the removal of the quinoline acid from the brain which minds blood
The method of appraising the removal of the quinoline acid from the brain which minds blood
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机译:评估从大脑中去除血液中喹啉酸的方法
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摘要
PROBLEM TO BE SOLVED: To construct an in vitro experiment system for reproducing quinolinic acid elimination and transportation in a blood-brain barrier by elucidating quinolinic acid elimination mechanism in a central nerve system.;SOLUTION: Transportation of quinolinic acid in the blood-brain barrier is evaluated by using a conditionally immortalized brain capillary endothelial cell. Consequently, existence of a transportation system for discharging quinolinic acid to the blood-brain barrier of the central nerve system is indicated. Discharge of quinolinic acid from the brain is evaluated by using the transportation system. Further, an evaluation system using TR-BBB13 cell being the conditionally immortalized brain capillary endothelial cell is excellent as a means for examining the influence of various compounds on uptake of quinolinic acid, newly provides an evaluation system useful for screening a medicine influencing discharge of quinolinic acid in the central nerve system and is extremely useful for developing a therapeutic agent for a central nerve disease in the blood-brain barrier.;COPYRIGHT: (C)2005,JPO&NCIPI
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