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Transformants and novel biosynthetic genes that produce secondary metabolites modified by functional groups
Transformants and novel biosynthetic genes that produce secondary metabolites modified by functional groups
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机译:产生由功能基团修饰的次级代谢产物的转化子和新型生物合成基因
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摘要
An objective of the present invention is to provide a transformant altered so as to produce a secondary metabolite in which a benzene ring of the secondary product is modified at the para-position with a functional group containing a nitrogen atom. A transformant according to the present invention is a transformant of an organism producing a secondary metabolite having a benzene ring skeleton without substitution at the para-position with a functional group containing a nitrogen atom, said transformant being transformed by introducing a gene involved in a biosynthetic pathway from chorismic acid to p-aminophenylpyruvic acid so as to produce a secondary metabolite having a benzene ring skeleton substituted at the para-position with a functional group containing a nitrogen atom. Another objective of the present invention is to provide a novel gene involved in the biosynthetic pathway from chorismic acid to p-aminophenylpyruvic acid. A novel gene according to the present invention comprises genes encoding the amino acid sequences of SEQ ID NOs: 2, 4 and 6 or modified sequences thereof. IMAGE
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机译:本发明的目的是提供一种经改变以产生次级代谢物的转化体,其中该次级产物的苯环在对位被含有氮原子的官能团修饰。根据本发明的转化体是生物体的转化体,该生物体产生具有苯环骨架而在对位上不被含有氮原子的官能团取代的次级代谢物,所述转化体通过引入涉及生物合成的基因而被转化。从分支酸到对氨基苯基丙酮酸的途径,以产生具有在对位上被含氮原子的官能团取代的苯环骨架的仲代谢产物。本发明的另一个目的是提供一种涉及从分支酸到对氨基苯基丙酮酸的生物合成途径的新基因。根据本发明的新基因包括编码SEQ ID NO:2、4和6的氨基酸序列或其修饰序列的基因。 <图像>
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