Use of kaurene compounds in pharmaceuticals

摘要

The invention relates the pharmaceutical use of kaurene compounds of formula (1) in treating and preventing coronary disease, stroke, cerebral ischemia and arrhythmia etc. The said compounds also have significant protecting effects against cerebral ischemic infarction. Wherein R 1 : hydrogen, hydroxyl or alkoxy R 2 : carboxyl, carboxylate, acyl halides, aldehyde, methylhydroxyl, and ester, acylamide, acyl or ether group hydrolysable to carboxyl. R 3 ,R 4 ,R 5 ,R 6 ,R 8 : independently, oxygen, hydroxyl, methylhydroxyl, and ester or alkyloxymethyl group hydrolysable to methylhydroxyl, R 7 : methyl, hydroxyl, and ester or alkyloxymethyl hydrolysable to methylhydroxyl,. R 9 : methylene or oxygen.