E2 receptor agonists prostaglandin which comprises, as an active ingredient, they -PGE1 compound 6-oxo, and methods for their preparation

摘要

PROBLEM TO BE SOLVED: To obtain a new compound scarcely binding to other subtype receptors, selectively and strongly binding to an EP1 receptor and useful as an antidepressant, an antiulcer agent, etc. ;SOLUTION: This compound is represented by formula I [A is a 4- to a 7-membered carbocyclic ring; R¹ is hydroxyl group, a 1-4C alkoxy or the like; R² is a (substituted) 1-8C alkylene, a (substituted) 3-8C alkenylene or the like; R³ is H, a 1-4C alkyl, a (substituted)phenyl or the like], preferably 2,5-ethano-6- oxo-17,20-dimethyl-PGE), etc. The compound is preferably obtained by eliminating a protecting group of hydroxyl group in a compound represented by formula II [Y is the protecting group of the hydroxyl group eliminable under acidic conditions; R^2a is a (substituted) 1-8C alkylene or a 3-8C alkenylene] under the acidic conditions.;COPYRIGHT: (C)1999,JPO