Method for treating prostate cancer using LHRH antagonist

摘要

Methods for treating sex hormone-dependent conditions are disclosed. The methods of the invention generally feature administration to a subject of an LHRH antagonist, in combination with a second therapy. In one embodiment, this second therapy is the performance of a procedure that removes or destroys tumor tissue, such as radical excision, cryosurgery or radiation therapy (external or interstitial). In another embodiment, the second therapy is treatment with an LHRH agonist, either simultaneously with or subsequent to LHRH antagonist therapy. The methods of the invention can further involve administering an antiandrogen and/or an inhibitor of sex steroid biosynthesis to the subject in combination with the LHRH antagonist. Methods for inhibiting the LHRH antagonist - induced hormone surge, whatever its clinical setting, are also disclosed. These methods generally involve administration of an LHRH antagonist in combination with the LHRH agonist. Complete suppression of the LHRH agonist-induced hormone surge has been achieved by pretreatment with a sustained-released formulation of LHRH antagonist.