首页>
外国专利>
Polymorphism of the gene encoding the monkey drug-metabolizing enzymes, and its use
Polymorphism of the gene encoding the monkey drug-metabolizing enzymes, and its use
展开▼
机译:猴类药物代谢酶编码基因的多态性及其应用
展开▼
页面导航
摘要
著录项
相似文献
摘要
The present invention aims to provide a method of subjecting to decide whether the fact that properly evaluating the effect on the pharmacokinetic studies, etc., including metabolism studies of new mfCYP2C, is used as an animal model monkeys. The present invention also provides an objective that for use as an animal model, a method is provided for selecting the monkey drug metabolism pattern is close to human, that, to provide a method for producing a monkey drug metabolism pattern is close to human to. By detecting a polymorphism in the new mfCYP2C gene, a method of evaluating whether or not to test the pharmacokinetics of the drug candidate compounds for human use, safety and efficacy and / or as an animal model monkeys, the present invention, the model How to select the monkey drug metabolism pattern is close to a human for use as an animal, there is provided a method and to produce a monkey drug metabolism patterns close to humans, further metabolic pattern of the drug provides a model subhuman animal very It is to.
展开▼