Polymorphism of gene encoding monkey drug-metabolizing enzyme and use thereof

摘要

The present invention aims to provide a method of subjecting to decide whether the fact that properly evaluating the effect on the pharmacokinetic studies, etc., including metabolism studies of new mfCYP2C, is used as an animal model monkeys. The present invention also provides an objective that for use as an animal model, a method is provided for selecting the monkey drug metabolism pattern is close to human, that, to provide a method for producing a monkey drug metabolism pattern is close to human to. By detecting a polymorphism in the new mfCYP2C gene, a method of evaluating whether or not to test the pharmacokinetics of the drug candidate compounds for human use, safety and efficacy and / or as an animal model monkeys, the present invention, the model How to select the monkey drug metabolism pattern is close to a human for use as an animal, there is provided a method and to produce a monkey drug metabolism patterns close to humans, further metabolic pattern of the drug provides a model subhuman animal very It is to.