Detection method of 4,7-dialkoxy -N- acetylneuraminic acid derivatives and influenza type A and B viruses in clinical samples,

摘要

(57) Abstract It is displayed with general system I, in R formula₁ and R₂ carbon atom is the alkyl group which includes 1 or 4, R₃ is pigment field characteristic and the fluorescent field characteristic basis, pigment - and the fluorescent field characteristic 4,7- jiarukokishi -N- acetyl neuraminic acid substrate is offered. These substrates are used, although the clinical sample or influenza A in the sample and B type are detected. You express in detail, if is, to use in order to identify the various viruses which possess neuraminidase activity it is possible these 4,7- jiarukokishi -N- acetyl neuraminic acid substrates. Making use of the 4,7- jiarukokishi -N- acetyl neuraminic acid derivative of this invention, for example para influenza to identify from 1, 2, 3 and 4 types and the mumpus it is possible influenza A and the B type virus. It offers the diagnostics which uses these substrates, identifies the influenza A in the clinical sample, and the B type virus it identifies from the other viruses which possess neuraminidase activity.