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Method for predicting the liver function and hepatic metabolism in humans of drug
Method for predicting the liver function and hepatic metabolism in humans of drug
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机译:预测药物人类肝功能和肝代谢的方法
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摘要
Provide a method to accurately predict the effect on liver function and hepatic metabolism in humans of the drug. In non-chimeric animals of the same species and non-human chimeric animal, has the body liver cell population of human origin that has the ability to grow, the hepatocytes population is responsible for the liver function of the chimeric animal substantially, of the hepatocytes and is characterized in that state where was protected against attack of human complement produced, then the test substance is administered, to analyze compares the metabolites of the non-chimeric animal and the chimeric animal, and hepatic metabolism of the test substance in human method for predicting liver function.
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