(57) Abstract (11 and 16) the -11,21- jihidorokishi -2'- methyl -5'H- pureguna -1,4- jieno [17,16-d] okisazoru -3,20- dione in the organic solvent which is suited manufacturing method of the chemical compound (11 and 16) -21- (acetyl oxy) -11- hydroxy -2'- methyl -5'H- pureguna -1,4- jieno [17,16-d] okisazoru -3,20- dione (dehurazakoruto) which includes the fact that it reacts with the acetic anhydride in the basic catalyst and under existing of the water.
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