Heterocyclic Amide Derivatives Which Possess Glycogen Phosphorylase Inhibitory Activity

摘要

A compound of the formula (1) or a pharmaceutically-acceptable salt, or pro-drug thereof; wherein, for example, Z is CH or nitrogen, R⁴ and R⁵ together are either —S—C(R⁶)═C(R7)— or —C(R⁷)═C(R⁶)—S—; R⁶ and R⁷ are independently selected from hydrogen, halo, nitro, cyano, hydroxy, fluoromethyl, difluoromethyl, trifluoromethyl, trifluoromethoxy, carboxy and carbamoyl; A is phenylene or heteroarylene; n is 0, 1 or 2; r is 1 or 2; R¹ is halo, cyano or carboxy; Y is selected from —C(O)R², —C(O)OR², —C(O)NR²R³, -(1-4C)alkyl [optionally substituted] -(2-4C)alkenyl, —SO₂NR²R³, and —S(O)_cR² (wherein c is 0, 1 or 2); R² and R³ are independently selected from hydrogen, —O(1-4C)alkyl, —S(1-4C)alkyl, —N(1-4C)alkyl, heterocyclyl, aryl, and (1-4C)alkyl [optionally substituted]; possess glycogen phosphorylase inhibitory activity and accordingly have value in the treatment of disease states associated with increased glycogen phosphorylase activity. Processes for the manufacture of compounds and pharmaceutical compositions containing them are described.;