SPECTROSCOPIC EXAMINATION OF BODY FLUID AND TISSUE SAMPLES TO AID DIAGNOSIS OF ALZHEIMER'S DISEASE

摘要

A method is described for the spectroscopic examination of samples which are taken from human tissue or body fluids, in particular blood, comprising the following steps: measuring an infrared spectrum of a sample to be examined; analysing the measured infrared spectrum in order to determine at least one sample parameter that characterizes the infrared spectrum in at least one of the following wavenumber ranges 2850 cm⁻¹ to 2886 cm⁻¹, 2798 cm⁻¹ to 2835 cm⁻¹, 1723 cm⁻¹ to 1733 cm⁻¹, 1429 cm⁻¹ to 1465 cm⁻¹, 1338 cm⁻¹ to 1364 cm⁻¹, 1089 cm⁻¹ to 1123 cm⁻¹, 1034 cm⁻¹ to 1074 cm⁻¹, comparing the at least one sample parameter with at least one reference parameter that was obtained by analysing at least one reference spectrum that was measured on at least one sample of body fluid from patients afflicted by Alzheimer's, and assigning the sample to a class with an increased suspicion of Alzheimer's disease if the deviation of the at least one sample parameter from the at least one reference parameter does not exceed a predetermined threshold value.