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Small Interfering Rna and Pharmaceutical Composition for Treatment of Hepatitis B Comprising the Same
Small Interfering Rna and Pharmaceutical Composition for Treatment of Hepatitis B Comprising the Same
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机译:小干扰RNA和药物组合物治疗包含乙肝的乙肝
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摘要
The present invention relates to RNA interference mediated inhibition of Hepatitis B virus (HBV) by short interfering RNA (siRNA) molecules. Specially, siRNAs of the present invention which are double-stranded RNAs concern directing the sequence-specific degradation of viral RNA in mammalian cells. Disclosed is a DNA vector encoding the RNA molecules and synthesized siRNA molecules as well as method of therapeutic treatment for inhibition of HBV gene expression and viral replication by the administration of RNA molecules of the present invention.
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