18-Methyl-19-norandrost-4-ene 17, 17-spiro ether (18-methyl-19-nor-20-spirox-4-en-3-one), and pharmaceutical products comprising the same

摘要

The present invention describes the novel 18-methyl-19-norandrost-4-ene 17,17-spiro ethers of the general formula I; ;in whichZ is an oxygen atom, two hydrogen atoms, a group ═NOR or ═NNHSO₂R, where R is a hydrogen atom or a straight- or branched-chain alkyl group having 1 to 4 or 3 to 4 carbon atoms,R⁴ is a hydrogen atom, a halogen atom or a trifluoromethyl group,and R⁶ and/or R⁷ may have a or a configuration, and R⁶ and R⁷ are independently of one another a hydrogen atom or a straight- or branched-chain alkyl group having 1 to 4 or 3 to 4 carbon atoms or a straight- or branched-chain alkenyl group having 2 to 4 or 3 to 4 carbon atoms or a saturated cycloalkyl group having 3 to 5 carbon atoms or together are a methylene group or a double bond.;The novel compounds have progestational and antimineralocorticoid activity.