SLITRK1 mutations associated with disorders in the OCD spectrum

摘要

The present invention provides compositions and methods directed to the use of SLITRK1 (slit and trk like 1) mutations to identify, diagnose, and treat disorders in the obsessive-compulsive disorder spectrum. Specifically, the present invention provides methods of identifying a subject having an increased risk of developing a disorder in the OCD spectrum and/or diagnosing a disorder in the OCD spectrum in a subject by detecting in the subject a mutation in the SLITRK1 gene.