Composition and method to inhibit tissue plasminogen activator (tPA) - potentiated neurotoxicity

摘要

The present invention relates to methods of treating, preventing or ameliorating ischemia-related, neural cell degeneration in a subject being treated with a thrombolytic agent, by administering to the subject one or more neuroprotective thiosemicarbazone compounds. More particularly, the present invention relates to methods of preventing, treating or ameliorating the adverse neurological side effects of tissue plasminogen activator, which is used in the treatment of ischemic stroke, by co-administering one or more compounds of the present invention. One such neuroprotective compound is PAN-811. The invention also relates to compositions comprising PAN-811 or analogs thereof in admixture with a thrombolytic agent, such as tPA.