This invention is directed to a method of treating depression in a subject, comprising the step of administering a therapeutically effective amount of a conventional antidepressant and, in addition, administering to the subject a therapeutically effective amount of a compound of Formula (I) or a pharmaceutically acceptable salt or ester thereof wherein Rx is a member Rx selected from the group consisting of hydrogen, lower alkyl of 1 to 8 carbon atoms, halogen selected from F, Cl, Br and I, alkoxy containing 1 to 3 carbon atoms, nitro, hydroxy, trifluoromethyl, and thioalkoxy containing 1 to 3 carbon atoms; x is an integer of 1 to 3, with the proviso that R may be the same or different when x is 2 or 3; R1 and R2 can be the same or different each other and are independently selected from the group consisting of hydrogen, lower alkyl of 1 to 8 carbon atoms, aryl, arylalkyl, cycloalkyl of 3 to 7 carbon atoms; R1 and R2 can be joined to form a 5 to 7-membered heterocycle substituted with a member selected from the group consisting of hydrogen, alkyl, and aryl groups, wherein the cyclic compound can comprise 1 to 2 nitrogen atoms and 0 to 1 oxygen atom, wherein the nitrogen atoms are not directly connected with each other or with the oxygen atom. 展开▼
机译:本发明涉及一种治疗对象的抑郁症的方法,该方法包括以下步骤:给予治疗有效量的常规抗抑郁药,此外,向对象给予治疗有效量的式(I)化合物或其中Rx是选自氢,具有1至8个碳原子的低级烷基,选自F,Cl,Br和I的卤素,含有1至3个碳原子的烷氧基,硝基,含1-3个碳原子的羟基,三氟甲基和硫代烷氧基; x是1至3的整数,条件是当x为2或3时R可以相同或不同; R 1 Sub>和R 2 Sub>可以彼此相同或不同,并且独立地选自氢,具有1至8个碳原子的低级烷基,芳基,芳基烷基3-7个碳原子的环烷基; R 1 Sub>和R 2 Sub>可以连接形成5至7元杂环,所述杂环被选自氢,烷基和芳基的成员取代,其中所述环状化合物可包含1-2个氮原子和0-1个氧原子,其中所述氮原子彼此不直接连接或不与氧原子直接连接。 <图像文件=“ US20080039529A1-20080214-C00001.GIF” he =“ 20.15mm” imgContent =“ chem” imgFormat =“ GIF” wi =“ 58.93mm” /> < /化学>
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