METHOD OF USING A COBALT-AMINE BASED METAL COMPLEX AS AN ANTIVIRAL COMPOUND AND A METHOD FOR THE PREPARATION OF FUNCTIONALIZED ANALOGS THEREOF

摘要

The present invention is generally directed to a method of prophylaxis against viral infection of a cell or subject or a method of treating a subject infected with a virus including administering an antiviral composition having the general Structure III,; wherein each of R₁, R₂, R₃, R₄, R₅ and R₆ is the same or different and includes an N-based ligand donor atom selected from the group consisting of ammonia, primary amine or secondary amine, or salt thereof. The present invention is also generally directed to a method of preparing an antiviral agent including providing a cobalt pentammine salt having a non-amine coordination site and mono-substituting the non-amine coordination site with a functional group incorporating a strong coordinator atom to cobalt to form a CoHex structure of Structure III, in which R₁ incorporates the functional group having the strong coordinator atom coordinated with the cobalt atom, or a salt thereof.