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Identification of gene sequences and proteins involved in vaccinia virus dominant T cell epitopes
Identification of gene sequences and proteins involved in vaccinia virus dominant T cell epitopes
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机译:鉴定牛痘病毒显性T细胞表位涉及的基因序列和蛋白质
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摘要
The present invention relates to the identification of gene sequences and proteins involved in vaccinia virus dominant T cell epitopes. Two vaccinia virus CD8+ T cell epitopes restricted by the most common human MHC class I allele, HLA-A0201 have been identified. Both epitopes are highly conserved in vaccinia and variola viruses. The induction of the T cell responses following primary vaccination is demonstrated by the kinetics of epitope specific CD8+ T cells in 3 HLA-A0201 individuals. This information will be useful for the design and analyses of the immunogenicity of experimental vaccinia vaccines, and for basic studies of human T cell memory.
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