Device and method for treating osteolysis using a drug depot to deliver an anti-inflammatory agent

摘要

The present invention relates to a device and method of treating an osteo-degenerative disease followed by an optional procedure using an osteoconductive material to accelerate healing of bone tissue damaged by the disease. The device for treating the bone degenerative disease comprises an in situ drug depot that time releases at least one anti-inflammatory agent. The method for treating an osteo-degenerative disease comprising: a) the combination of at least one anti-inflammatory agent with a flowable drug carrier, b) delivering the flowable drug carrier/anti-inflammatory mixture to a bone lesion, c) in situ curing of the mixture forming a rigid drug depot, d) wherein the drug depot bio-resorbs releasing the anti-inflammatory agent over time to treat a degenerative bone disease), and e) followed by an optional treatment using an osteoconductive material in combination with a growth factor.