首页>
外国专利>
Two-step method to align three dimensional LC-MS chromatographic surfaces
Two-step method to align three dimensional LC-MS chromatographic surfaces
展开▼
机译:两步法对准三维LC-MS色谱图表面
展开▼
页面导航
摘要
著录项
相似文献
摘要
A two-step alignment method for temporally aligning LC-MS data files representative of three-dimensional chromatographic surfaces is disclosed. The method includes a pre-alignment step whereby the data files are roughly aligned using a transformation-based correlation analysis of base peak information. The pre-aligned files are used as input to a full alignment step, in which a correlation matrix is computed from the full MS scan information, and an optimal path is traced through the resultant correlation matrix to identify corresponding scan numbers. The use of the pre-alignment step substantially reduces the computational expense of the full alignment step and improves the accuracy and reliability of the alignment.
展开▼