LAYOUT METHOD FOR PROTEIN-PROTEIN INTERACTION NETWORKS BASED ON SEED PROTEIN

摘要

Provided is a layout method for protein-protein interaction networks based on a seed protein, which is for performing multiple stages of nesting centered on a node having a high degree of physical relationship, and performing multiple stages of extension and force directed placement (FDP) with respect to a final nest graph. The layout method includes the steps of: a) extracting a node list of each sub-graph constituting a protein-protein interaction network, and aligning the node list according to adjacency of nodes; b) selecting a seed protein from the aligned node list according to node priority and nest relationship with another node; c) nesting adjacent nodes centered on the selected seed protein to generate a nested node; and d) selecting an initial position of the generated nested node, placing the nodes of the nested nodes on respective division points, centered on the seed protein, and then performing layout.