Molecular based two-marker assays that predict outcome of adenocarcinoma patients

摘要

Provided is a method of identifying a subject at risk of recurrence of adenocarcinoma, comprising detecting markers associated with recurrence. Provided is a method of identifying a subject at risk for recurrence of adenocarcinoma, comprising determining the ratio of EpCAM2 to CK19 in primary adenocarcinoma tissue from the subject, a high ratio of EpCAM2 to CK19 M indicating a subject at risk for recurrence. Also provided is method of identifying a subject at risk for recurrence of adenocarcinoma, comprising determining the ratio of CK19 and P-cadherin in primary adenocarcinoma tissue from the subject, a low ratio of CK19 to P-cadherin indicating a subject at risk for recurrence. A method of identifying a subject at risk for recurrence of adenocarcinoma is provided, comprising determining the ratio of Map7 to EpCAM2 in primary adenocarcinoma tissue from the subject, a low ratio of Map7 to EpCAM2 indicating a subject at risk for recurrence. Provided is a method of identifying a subject at risk for recurrence of adenocarcinoma, comprising determining the ratio of P-cadherin to E-cadherin in primary adenocarcinoma tissue from the subject, a high ratio of P-cadherin to E-cadherin indicating a subject at risk for recurrence.