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Modulation of Inflammation Through Modulation of Elavl1/HuR Expression
Modulation of Inflammation Through Modulation of Elavl1/HuR Expression
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机译:通过调节Elavl1 / HuR表达调节炎症
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摘要
In the present invention modulation of expression of a member of the Elavl1/Hu family is used to modulate at least translation of specific mRNA. Inducible increase of HuR in murine innate compartments suppresses inflammatory responses in vivo. HuR over-expression induced the translational silencing of specific cytokine mRNAs, despite positive or nominal effects on their corresponding turnover. The present invention uses the fact that HuR acts in a pleiotropic fashion in inflammation through its functional interactions with specific mRNA subsets and negative posttransciptional modules.
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