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Method for diagnosing a transmissible spongiform subacute encephalopathy caused by an unconventional transmissible agent strain in a biological sample
Method for diagnosing a transmissible spongiform subacute encephalopathy caused by an unconventional transmissible agent strain in a biological sample
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机译：诊断由生物样品中非常规传染性病原菌引起的传染性海绵状亚急性脑病的方法
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摘要
The invention relates to a method for diagnosing a transmissible spongiform subacute encephalopathy (TSSE) caused by an unconventional transmissible agent (UTA) or prion. The method involves treating a sample suspected of containing a prion with proteinase K for a time and under conditions that completely degrade normal prion protein (Prp-sen), but which only partially digest abnormal prion protein (PrP-res) so that all or some of the octapeptide motif repeats comprising P(H/Q)GGG(-/T)WGQ (SEQ ID NO: 1) in the abnormal prion protein (Prp-res) are retained.
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机译：本发明涉及一种诊断由非常规可传播剂（UTA）或病毒引起的可传播性海绵状亚急性脑病（TSSE）的方法。该方法包括在完全降解正常and蛋白（Prp-sen），但仅部分消化异常abnormal蛋白（PrP-res）的条件下，用蛋白酶K处理怀疑含有a病毒的样品一段时间。保留了异常病毒蛋白（Prp-res）中包含P（H / Q）GGG（-/ T）WGQ（SEQ ID NO：1）的八肽基序重复序列。
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