Acylhydrazone derivatives and the use thereof in the inhibition, regulation and/or modulation of kinase signal transduction

摘要

The invention relates to acylhydrazone derivatives of formula (I), which are SGK inhibitors and can be used for the treatment of diseases and afflictions associated with SGK, such as diabetes, obesity, metabolic syndrome (dyslipidaemia), systematic and pulmonary hypertension, cardiovascular diseases and kidney diseases and in general for all types of fibroses and inflammatory processes. In said formula: R¹ and R⁵ independently of one another represent H, OH, OA, OAc or methyl; R², R³, R⁴, R⁶, R⁷, R⁸, R⁹ and R¹⁰ independently of one another represent H, OH, OA, OAc, OCF₃, Hal, NO₂, CF₃, A, CN, OSO₂CH₃, SO₂CH₃, NH₂, or COOH; R¹¹ represents H or CH₃; A represents an alkyl comprising 1, 2, 3, or 4 C atoms; X represents CH₂, CH₂CH₂, OCH₂ or —CH(OH)— and Hal represents F, Cl, Br or I.;