L-nucleosides as ligands to adenosine receptors

摘要

Disclosed herein are compounds having Formula I, which are non-natural L-adenosine analogs. Also disclosed are their methods of making. Still further, disclosed are the uses of the disclosed compounds to treat cardiovascular disease, ischemia related injuries; and neurodegenerative diseases. The compounds disclosed herein have the formula:; wherein R¹ and R² are, independently, H, branched or straight-chain, substituted or unsubstituted alkyl, alkenyl, alkynyl, or aryl; R³ is branched or straight-chain, substituted or unsubstituted alkyl, hydroxy-alkyl, or —C(═O)NR⁶R⁷; and R⁴ and R⁵ are, independently, H, hydroxy, halogen, and NR⁸R⁹,wherein R⁶, R⁷, R⁸, and R⁹ are, independently, H, branched or straight-chain, substituted or unsubstituted alkyl, alkenyl, alkynyl, or aryl.