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Formulation based on heparin, glycosaminoglycan or heparinoid, use of the formulation and the formulation base
Formulation based on heparin, glycosaminoglycan or heparinoid, use of the formulation and the formulation base
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机译:基于肝素,糖胺聚糖或类肝素的制剂,制剂的用途和制剂基质
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摘要
The present invention relates to formulations based on at least one heparin, glycosaminoglycan or heparinoid and on a formulation base with a lipid component and a polymer component. The use of this formulation as drug form for oral administration of at least one heparin, glycosaminoglycan or heparinoid, and also a process for producing the formulations by mixing the formulation components to form a plastic mixture and, where appropriate, to manufacture the formulations as drug form, advantageously using melt extrusion, are described. The lipid component advantageously has active ingredient-promoting properties, while the polymer component is soluble or swellable. At least parts of the lipid component are embedded in a polymer matrix, preferably in the form of a molecular dispersion. The formulations can form emulsions in water or aqueous liquids.
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