Inhibitors of 11 beta hydroxysteroid dehydrogenase Type 2 diabetes - 1 - 1 - and Pharmaceutical composition

摘要

Claim 1: A compound of formula (I): wherein: R 1 is aryl, heteroaryl, aralkyl, heteroaralkyl, lower alkyl, lower alkoxy-benzyl, lower alkoxy-carbonyl-lower alkyl, lower haloalkyl, hydroxy-lower alkyl, alkoxy lower-lower alkyl, (CH2) s-aryl, (CH2) s-heteroaryl or (CH2) s-cycloalkyl, wherein said aryl, heteroaryl, aralkyl, heteroaralkyl (CH2) s-aryl, (CH2) s-heteroaryl or (CH2) s-cycloalkyl is substituted or unsubstituted with one or more substituents selected from the group consisting of halogen, lower alkyl, lower alkoxy, cyano, lower alkoxycarbonyl, lower haloalkyl,Phenyl - (oxo low tar) and hydroxy low tar; P is 0 or 1; s is 0, 1 or 2; R2 is phenyl, which can be replaced or replaced without hesitation by one or more substitutes selected from halogenation, hydrogen group, low halogen group, low oxygen, trifluoromethy, carbamate, low tar, nitrate and cyanogen, 2. Diphenyl, one or more substitutes selected from the group of acetyl, halogenated, low acid and low oxygen carbides, sulfonamide, lower alkyl sulfuryl, low acid and low oxygen carbides, lower halogen subunit, substituted or unsubstituted naftil which can not be replaced or substituted by diphenyl;a 5 or 6 membered monocyclic heterocycle with 1-3 atoms selected from N, O and S, which may be unsubstituted or substituted with halogen, lower alkyl, substituted or unsubstituted phenyl, or lower haloalkyl, or substituted or unsubstituted benzothiophene , as long as the following compounds are excluded: 1,7,8,8-tetramethyl-2-phenyl-1,2,4,5,6,7-hexahydro-4,7-methane-indazol-3- one, 2,7,8,8-tetramethyl-1-phenyl-1,2,4,5,6,7-hexahydro-4,7-methane-indazol-3-one, 1,7,8,8-tetramethyl- 2-Naphthalen-2-yl-1,2,4,5,6,7-hexahydro-4,7-methane-indazol-3-one, 1,7,8,8-tetramethyl-2-p-tolyl- 1,2,4,5,6,7-hexahydro-4,7-methane-indazol-3-one,2 - (4-methyl-phenyl) - 1,7,8,8-tetramethyl-1,2,4,5,6,7-hexahydro-1,2,4,5,6,7-hexahydro-4,7-methane-indazol-3-ona and 1,7,8,8-tetramethyl-2-o-methanol-1,2,4,5,6,7-hexahydro-4,7-methane-indazol-3-ona.