Compound diazaespiro - acetamide Derivative, Pharmaceutical composition containing same and use for preparing a drug for treating a disorder mediated by GlyT1 and Process for its preparation

摘要

Diazaspiro-acetamide derivative compound of formula (1) or a salt or solvate thereof: where: R1 is selected from H, C1-4 alkyl, C1-4 alkoxy, halo, C1-4 haloalkyl, C1-4 haloalkoxy, alkylthio C 1-4, C 3-6 cycloalkyl, C 1-4 alkylsulfonyl, C 1-4 alkoxy-C 1-4 alkyl and cyano; R 2 is selected from H, C 1-4 alkyl, C 1-4 alkoxy, halo, C 1-4 haloalkyl, C 1-4 haloalkoxy, C 1-4 alkylthio, C 3-6 cycloalkyl, C 1-4 alkylsulfonyl, C 1-4 alkoxy-C 1 alkyl -4 and cyano; R3 is selected from H, methyl, ethyl, C1-4 alkoxy, halo, C1-4 haloalkyl, C1-4 haloalkoxy, C1-4 alkylthio, C3-6 cycloalkyl, C1-4 alkylsulfonyl, C1-4 alkoxy-C1- alkyl 4 and cyano;O R2 and R3 are added together to form a slave-o-ch2-o-y-o-ch2-ch2-oR4 is selected from H, C 1-4 alkyl, C 1-4 alkoxy, halo, C 1-4 haloalkyl, C 1-4 haloalkoxy, C 1-4 alkylthio, C 3-6 cycloalkyl, C 1-4 alkylsulfonyl, C 1-4 alkoxy-C 1 alkyl -4 and cyano; R5 is selected from H, C 1-4 alkyl, C 1-4 alkoxy, C 1-4 haloalkyl, C 1-4 haloalkoxy, halo, cyano, and C 1-4 alkoxy-C 1-4 alkoxy; R7 is selected from H, C1-4alkyl, C1-4alkoxy, C1-4haloalkyl, C1-4haloalkoxy, halo, cyano and C1-4alkoxy-C1-4alkoxy with the proviso that when R5 is selected from H , methyl methoxy, chlorine and fluorine, then R7 is not H; R6 is selected from H and methyl; R8 is selected from H and fluoro; and n is selected from 0, 1 and 2. A pharmaceutical composition comprising it,I use an effective drug to treat a disease treated by giyt1, such as schizophrenia, dementia or attention deficit disorder. The process of preparation.