Compound of aryl diazaespiro oxo Intermediate for Synthesis, use thereof for preparing a Medicament for the treatment of a disorder mediated by GlyT1, Pharmaceutical Composition and Association that comprise it.

摘要

Compuesto derivado del aril-oxo-diazaespiro amidas o cetonas de formula o una sal del mismo en el que R1 se selecciona de hidrogeno alquilo C1-4 alcoxi C1-4 halo haloalquilo C1-4 haloalcoxi C1-4 alquil C1-4 tio cicloalquilo C3 [C1-4 alkyl] sulfonyl, [C1-4 alkoxy] C1-4 alkyl, cyano CONRcRd (wherein Rc and Rd are independently selected from H and C1-4 alkyl or Rc and Rd, together with the nitrogen atom at which are attached, form a 4- to 7-membered ring; R3 selects from hydrogen, C1-4 alkyl, C1-4 alkoxy, halo, C1-4 haloalkyl, C1-4 haloalkoxy, [C1-4 alkyl] thio, C3 cycloalkyl -6, (C3-6 cycloalkyl) C1-4 alkyl, (C1-4 alkyl) sulfonyl, [C1-4 alkoxy] C1-4 alkyl, cyano and CONReRt (wherein Re and Rf are independently selected from H and alkyl C1-4 or Re and Rf, together with the nitrogen atom to which they are attached, form a 4- to 7-membered ring);O R2 and R3 constitute a selected o-ch2-o-y-o-ch2-ch2-o -;R4 is selected from: hydrogen, C1-4 alkyl; halo, C1-4 haloalkyl, C1-4 haloalkoxy, [C1-4 alkyl] thio, C3-6 cycloalkyl, [C3-6 cycloalkyl] C1-4 alkyl, (C1-4 alkyl sulfonyl, (C1-4 alkoxy) alkyl C1-4, cyano and CONRgRh (where Rg and Rh are indecently selected from H and C1-4 alkyl or Rg and Rh, together with the nitrogen atom to which they are attached, form a 4- to 7-membered ring);R5 is selected from: hydrogen, chlorine, fluorination, C1-4 and CF3; R6 is selected from: (alcox C1-4) tar (C1-4 tar), sulfur (C1-4 tar), uncle, cor9 (R9 is hydrogen gene or C1-4 tar); conrirj (in this case, RI and RJ are selected to be independent of C1-4 or hydrocarbon group, Form a 4, 5 or 6-ring and chrkrlrm with the nitrogen atoms connected together (RK is the hydrogen or tar of C1-4 and RL / RM, regardless of C1-4 or RL / RM, plus the nitrogen atoms attached together to form a 4, 5 or 6-member ring);R15 is hydrogen or fluorine; R7 is selected from the following substances: hydrogen, C1-4 tar, alcox C1-4, halogenated C1-4, halogenated C1-4 carbon, cyanogen (Alcoy C1-4) alcox C1-4 and (alcox C1-4) C1-4 tar; R8 is selected from hydrogen and methyl, and M is selected from 0, 1 and 2. Its purpose is to produce an effective drug for the treatment of glytl's intermediate disorders, such as schizophrenia, dementia and attention deficit disorders. Drug composition and association with one or more therapeutic agents Synthesized by middlemen ILO Convention No. 12: an intermediary integrates the first provision of ILO Convention No. 1.It is a formula (II) or a salt, wherein R6 is selected from (alcox C1-4) C1-4 tar (C1-4 tar) sulfuric acid (C1-4 tar) uncle and cor9 (wherein R9 is C1-4 hydrocarbon),Conrirj (in this case, RI and RJ are selected to form a ring of 4, 5 or 6 members independent of or connected to the nitrogen atom of C1-4 hydrogen or hydrocarbon base): R15 is hydrogen or fluorine; R7 is selected as: hydrogen, C1-4 hydrocarbon base, alcox C1-4, halo-4, halo alcox C1-4, halo, ciao, C1-4 (alcox C1-4) alcox c1-4y (alcox C1-4) C1-4 tar; R8 was selected from 0.1 and 2 as hydrogen and methyl.