MGluR5 modulators of metabotropic glutamate receptors, Pharmaceutical compositions containing them and uses in pathophysiological processes and disorders that affect the SNA

摘要

Claim 1: a compound of formula (1) wherein R1 is Hydrogen or Fluorine; R2 is Hydrogen, Fluorine or c1-3 alkyl; R3 is c1-3 alkyl or ciclopropilo; X is (2) and (3) where z is R4 is Hydrogen, c1-3 alkyl, c1-3 haloalquilo C1, C1 - alkoxy - 3; 3 haloalcoxi; Halogen; R5 is Hydrogen, C1 - 3 Haloalquilo c1-3 alkyl, alkoxy, c1-3; haloalcoxi c1-3; R6 is Hydrogen, halogen or;Fluoro c1-3 alkyl or its Salts, as well as acceptable for pharmaceutical use, hydrates, isoforms, tautomeros and / or enantiomers.