MGluR5 modulators of metabotropic glutamate receptors, Pharmaceutical compositions containing them and uses in pathophysiological processes and disorders that affect the SNA

摘要

Claim 1: a compound of formula (1) wherein R1 is Methyl, cyano or Halogen; R2 is Hydrogen or Fluorine; R3 is Hydrogen, Fluorine or c1-3 alkyl; R4 is Hydrogen or c1-3 alkyl; X is (2) and (3); Z is R5 is Hydrogen, C1 - 3 haloalquilo c1-3 alkyl, alkoxy, c1-3; or c1-3 haloalcoxi hidrog R6; Eno, c1-3 alkyl or haloalquilo, c1-3, c1-3 haloalcoxi R7 is Hydrogen;Fluoro or c1-3 alkyl; and its pharmaceutical use for acceptable salts, hydrates, tautomeros isoforms, and / or enantiomers.