Azaindol Derivatives with a combination of nicotinic acetylcholine receptor partial agonism and inhibition of reuptake of dopamine

摘要

These compounds have a combination of nicotinic acetylcholine receptor partial agonism and inhibition of dopamine reuptake.It also relates to pharmaceutical compositions containing these Compounds, to methods for preparing Compounds, Methods for preparing Intermediates useful for their Synthesis, and Methods for preparing compositions and Uses of such compounds and compositions.Particularly use in Administration to patients to achieve a therapeutic effect in Disorders involving nicotinic receptors and / or dopamine Transporter or that can be treated via the Manipulation of such receptors.Claim 1: azaindol derived Compounds, characterized by the General formula (1), where X, y and Z represent independently N or C, with the condition that the Ring contains at least one n Atom, and not more than 2; M and N are independently either 1 or 0 (Zero), the condition d And when Z and x represents represent Carbon and NitrogenM is 0 (Zero); R2 and R3 are independently Hydrogen, halogen, alkyl alquinilo C1 C1 - 3, - 3, - NH c1-3 alkyl, hydroxyl, alkyl of C1 - 3oxi, or a Group piperidinilo, pirrolidinilo, tetrahidropiridinilo, morfolinilo, azepanilo, 1 - aza Bicyclo [2.2.2] octanilo or 1 - aza Bicyclo [2.2.2] oct - 2 - enilo, or insubstituido or group that is substituted with one or more substituents selected from Halogen, c1-3 alkyl, phenyl or benzyl; R4, R5 and R6 independently represent Hydrogen, halogen, alkyl of C1 - C2 alquinilo 3, - 3, - NH c1-3 alkyl or alkyl, hydroxyl - 3oxi C1, C That exists only when ondicion R4 and R5 only when z = C, c = tautomeros; and,N - Oxides and stereoisomers thereof, and pharmacologically acceptable salts, hydrates and solvates of said compounds of formula (1) and its tautomeros, stereoisomers and N - oxides, compounds that have a combination of nicotinic acetylcholine receptor partial agonism and R Nhibicion reuptake of dopamine.