viral particle consisting of structural elements not derived from an alpha virus and containing an alpha virus vector, use of the viral particle and process for obtaining viral particles

摘要

VIRAL PARTICULATE CONSTITUTED OF STRUCTURAL ELEMENTS NOT FROM AN ALPHA VIRUS AND CONTAINING AN ALVIRUS DERIVED VECTOR, USE OF THE VIRAL PARTICLE AND PROCEDURE FOR OBTAINING VIRAL PARTICULAR PARTICULARS from an alphavirus and containing an alphavirus-derived vector rendered defective for replication by deletion or substitution by at least one transgene of structural genes characterized in that the structural elements of said particle are not encoded by the genome of the alpha virus derived vector, proceeded from the production of said particle consisting of expressing in i trans /i in a cell line the genes encoding the non-emitted structural elements of the alpha virus and the derived vector alpha virus and recovering the viral particles present in the cell culture supernatant.