chemical entity, pharmaceutical composition, methods of treating heart disease, modulating the cardiac sarcomere, and potentiating cardiac myosin in a mammal, use of a chemical entity, and method of preparing a compound

摘要

CHEMICAL ENTITY, PHARMACEUTICAL COMPOSITION, HEART DISEASE TREATMENT METHODS, TO MODULATE HEART SARCEMER, AND TO POTENTIALIZE CARDIAC MYOSIN IN A MAMMER, USE OF A CHEMICAL COMPLETE EFFECT OF A CHEMICAL COMPOUND Substituted urea drugs that selectively modulate the cardiac sarcomere, for example by potentiation of cardiac myosin, and are useful in the treatment of systolic heart failure including congestive heart failure.