method of effecting prophylaxis or treating a disease, pharmaceutical composition, monoclonal antibody, hybridoma cell, and method of screening an agent, humanizing monoclonal antibody 8a5 or monoclonal antibody 6h7 and producing a chimeric form of monoclonal antibody 8a5 or monoclonal antibody 6h7

摘要

METHOD OF CARRYING OUT PROPHYLAXIS OR TREATING A DISEASE PHARMACEUTICAL COMPOSITION, MONOCLONAL ANTIBODY, HYBRIDOMA CELL, AND METHODS OF TRIALING AN AGENT, HUMANIZING MONOCLONAL ANALOGUE 8A5 OR7 MONOTICAL ANALOGUE The invention provides improved methods and agents for the treatment of diseases associated with synucleinopathic diseases, including Lewy bodies and alpha-synuclein in a patient's brain. Such methods include administering agents that induce a beneficial immunogenic response against Lewy bodies. The methods are particularly useful for prophylactic and therapeutic treatment of Parkinson's disease.