multipurpose RNA molecules comprising at least one aptamer for the application of double-stranded RNA to pest organisms

摘要

MULTIDOMAIN RNA MOLECULES UNDERSTANDING AT LEAST ONE APPLICATION FOR DOUBLE CORD RNA APPLICATION TO PEST ORGANISMS, particularly The present invention relates to methods and constructs for the application of double stranded RNA (dsRNA) to organisms. of plague. More specifically, the invention relates to a multi-domain RNA molecule consisting of a nucleotide sequence comprising (i) at least one aptamer and (ii) at least one nucleotide sequence of interest forming double stranded RNA. wherein said double stranded RNA comprises the complementary stranded strands, each of which comprises a nucleotide sequence that is complementary to at least part of a plague target nucleotide sequence. The invention further relates to nucleic acids encoding multi-domain RNA molecules and various uses of multi-domain RNA molecules in agriculture.