Process for Preparation of 1,2,4 - Oxadiazoles benzoic acid or a pharmaceutically acceptable Salt of this comprising reacting an acid methyl ester cianobenzoico with hydroxylamineAcilar chloride halobenzoilo, condense and Hydrolyze and

摘要

Provided herein are processes for the preparation of compounds useful for the treatment, prevention or management of diseases associated with a nonsense mutation. More specifically, provided herein are processes for the synthesis of 1,2,4-oxadiazoles. In particular, provided herein are processes useful for the preparation of 3-[5-(2-fluorophenyl)-[1,2,4]oxadiazol-3-yl]-benzoic acid.