首页>
外国专利>
Anhydrate or hydrate of N - Methyl Naltrexone; Preparation procedure, useful for reducing the side effects of morphine, especially at the level of the Gastrointestinal Tract.
Anhydrate or hydrate of N - Methyl Naltrexone; Preparation procedure, useful for reducing the side effects of morphine, especially at the level of the Gastrointestinal Tract.
展开▼
机译:N-甲基纳曲酮的无水物或水合物;制备步骤,可用于降低吗啡的副作用,尤其是在胃肠道方面。
展开▼
页面导航
摘要
著录项
相似文献
摘要
The invention relates to a novel process for preparing N-methylnaltrexone bromide, comprising at least the steps consisting in: (i) reacting N-methylnaltrexone methyl sulfate in aqueous solution with an alkaline agent chosen from the group constituted by sodium carbonate, potassium carbonate, calcium carbonate, magnesium carbonate, cesium carbonate, strontium carbonate and mixtures thereof, for a pH of the aqueous reaction medium of between 7 and 10, and then in (ii) reacting the product thus obtained with hydrobromic acid, which is added for a pH of the aqueous reaction medium of between 0.5 and 5, in order thus to obtain the N-methylnaltrexone bromide.
展开▼