Compounds derived from 2-piperidyl - propane - thiols, modulators of chemokine receptor activity, Pharmaceutical Composition and use for Treatment of Asthma and allergic diseases, COPDInfections by pathogenic Microbes, rheumatism arthritis

摘要

One object of the present invention are novel substituted piperidyl-propane-thiols of the formula (1), wherein R1, R2, R3 and R4 are defined as below. Another object of the present invention is to provide agonists or antagonists of CCR-3, or pharmaceutically acceptable salts thereof, more particularly to provide pharmaceutical compositions comprising a pharmaceutically acceptable carrier and a therapeutically effective amount of at least one of the compounds of the present invention or a pharmaceutically acceptable salt thereof.