Quinoline derivatives and compounds tetrahidroquinolina,With Inhibitory activity; Pharmaceutical composition comprising these Compounds, and their use to treat a headache as migrana, Chronic Pain, disorders of the nervous system

摘要

The present invention features quinolones, tetrahydroquinolines, and related compounds that inhibit nitric oxide synthase (NOS), particularly those that selectively inhibit neuronal nitric oxide synthase (nNOS) in preference to other NOS isoforms. The NOS inhibitors of the invention, alone or in combination with other pharmaceutically active agents, can be used for treating or preventing various medical conditions.