Substituted indole Compounds, inhibitors of the 5-lipoxygenase Activating Protein (flap), Pharmaceutical Composition and use in the treatment of diseases such as COPD.Cardiovascular disease and inflammation.

摘要

Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of 5-lipoxygenase-activating protein (FLAP). Also described herein are methods of using such FLAP modulators, alone and in combination with other compounds, for treating respiratory, cardiovascular, and other leukotriene-dependent or leukotriene mediated conditions or diseases.