Quinolone agents as inhibitors of receptor Tyrosine Kinases and the synthesis of the same

摘要

The fourth method for the preparation of kunnorin compounds was replaced by the middleman for the preparation of kunnorin thyroid inhibitors and the intermediate compounds used in this method. Among them, the fourth kunnorin substitute proposed the following general formula (I): and replaced LG in it. "(PG, a, G, R1 and) R4 is described in the descriptive report.