Medicament carriers based on modified poly(ethylene) glycols and pH-sensitive conjugates thereof

摘要

nosice aminolu00e9civ based on modified poly (ethylene glycol) with a molecular weight of 600 to 40 000obsahuju00ed at least one end coupling - x - y - cho, where x is o, nh, nhco,dad, and y is a saturated or unsaturated, vetvenu00fd ci chondrites nevetvenu00fd chain of command with poctem carbon 1 to 20, or phenylene.the use of nosice kpru00edprave conjugate with a ph sensitive iminovazbou resulting from the reaction aminoskupiny lu00e9civa with binding end aldehydickou group end couplings of modified poly (ethylenglykolovu00e9ho) nosice whose aim of research is damaged tissue characterized by reduced ph versus ph beu017enu00e9mu in blood and healthy tissues. conjugates with amphotericin b and nystatinem and method of their preparation.