Medicament carriers based on modified poly(ethylene) glycols and pH-sensitive conjugates thereof

摘要

Nosice aminoléciv of modified poly (ethylene glycol) having a molecular weight from 600 to 40 000obsahují least one end connector -XY-CHO, wherein X is O, NH, NHCO, OCO and Y is a saturated or unsaturated, straight chain or branched carbon chain having a carbon number 1 to 20, or phenylene. Carrier used to preparation of a conjugate with a pH - sensitive iminovazbou formed by reacting the amino group of drugs with binding terminal aldehyde group of end connectors modified poly (ethylene glycol) carrier aimed effect is tissue damage characterized by a reduced pH compared to a conventional pH in blood and healthy tissues. Conjugates with amphotericin B and nystatin and the process of their preparation.